Publications
2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015
Keramidioti A, Schneid S, Busse C, Cramer von Laue C, Bertulat B, Salvenmoser W, Hess M, Alexandrova O, Glauber KM, Steele RE, Hobmayer B, Holstein TW and David CN (2024). A new look at the architecture and dynamics of the Hydra nerve net. Elife, 12, RP87330. https://doi.org/10.7554/eLife.87330.3
Palikyras S, Sofiadis K, Stavropoulou A, Danieli-Mackay A, Varamogianni-Mamatsi V, Hörl D, Nasiscionyte S, Zhu Y, Papadionysiou I, Papadakis A, Josipovic N, Zirkel A, O'Connell A, Loughran G, Keane J, Michel A, Wagner W, Beyer A, Harz H, Leonhardt H, Lukinavicius G, Nikolaou C and Papantonis A (2024). Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor. Aging Cell, 9, e14083. https://doi.org/10.1111/acel.14083
Lebedev M, Chan FY, Lochner A, Bellessem J, Osório DS, Rackles E, Mikeladze-Dvali T, Carvalho AX and Zanin E (2023). Anillin forms linear structures and facilitates furrow ingression after septin and formin depletion. Cell Rep, 42, 113076. https://doi.org/10.1016/j.celrep.2023.113076
Forsthofer M and Straka H (2023). Homeostatic plasticity of eye movement performance in Xenopus tadpoles following prolonged visual image motion stimulation. J Neurol., 270, 57-70. https://doi.org/10.1007/s00415-022-11311-8
Schmacke NA, O'Duill F, Gaidt MM, Szymanska I, Kamper JM, Schmid-Burgk JL, Mädler SC, Mackens-Kiani T, Kozaki T, Chauhan D, Nagl D, Stafford CA, Harz H, Fröhlich AL, Pinci F, Ginhoux F, Beckmann R, Mann M, Leonhardt H and Hornung V (2022). IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network. Immunity, 55, 2271-2284.e7. https://doi.org/10.1016/j.immuni.2022.10.021
Qin W, Steinek C, Kolobynina K, Forné I, Imhof A, Cardoso MC and Leonhardt H (2022). Probing protein ubiquitination in live cells. Nucleic Acids Res., 50, e125. https://doi.org/10.1093/nar/gkac805
Gordy C and Straka H (2022). Developmental eye motion plasticity after unilateral embryonic ear removal in Xenopus laevis. iScience, 25, 105165. https://doi.org/10.1016/j.isci.2022.105165
Simmet K, Kurome M, Zakhartchenko V, Reichenbach HD, Springer C, Bähr A, Blum H, Philippou-Massier J and Wolf E (2022). OCT4/POU5F1 is indispensable for the lineage differentiation of the inner cell mass in bovine embryos. FASEB J., 36, e22337. https://doi.org/10.1096/fj.202101713RRR
Zhang L, Isselstein M, Köhler J, Eleftheriadis N, Huisjes N, Guirao M, Narducci A, Smit J, Stoffels J, Harz H, Leonhardt H, Herrmann A and Cordes T (2022). Linker Molecules Convert Commercial Fluorophores into Tailored Functional Probes during Bio-labeling. Angew Chem Int Ed Engl., 61, e202112959. https://doi.org/10.1002/anie.202112959
Brandstetter K, Zülske T, Ragoczy T, Hörl D, Guirao-Ortiz M, Steinek C, Barnes T, Stumberger G, Schwach J, Haugen E, Rynes E, Korber P, Stamatoyannopoulos JA, Leonhardt H, Wedemann G and Harz H (2022). Differences in nanoscale organization of regulatory active and inactive human chromatin. Biophys J., 121, 977-990. https://doi.org./10.1016/j.bpj.2022.02.009
Landspersky T, Saçma M, Rivière J, Hecker JS, Hettler F, Hameister E, Brandstetter K, Istvanffy R, Romero Marquez S, Ludwig R, Götz M, Buck MC, Wolf M, Schiemann M, Ruland J, Strunk D, Shimamura A, Myers KC, Yamaguchi TP, Kieslinger M, Leonhardt H, Bassermann F, Götze KS, Geiger H, Schreck C and Oostendorp RAJ (2021). Autophagy In Mesenchymal Progenitors Protects Mice Against Bone Marrow Failure After Severe Intermittent Stress. Blood, 139, 690-703. https://doi.org/10.1182/blood.2021011775
Springer C, Zakhartchenko V, Wolf E and Simmet K (2021). Hypoblast Formation in Bovine Embryos Does Not Depend on NANOG. Cells, 10, 2232. https://doi.org/10.3390/cells10092232
Jakubke C, Roussou R, Maiser A, Schug C, Thoma F, Bunk D, Hörl D, Leonhardt H, Walter P, Klecker T and Osman C (2021). Cristae-dependent quality control of the mitochondrial genome. Sci Adv., 7, 36. https://doi.org/10.1126/sciadv.abi8886
Gao L, Meiring JCM, Kraus Y, Wranik M, Weinert T, Pritzl SD, Bingham R, Ntouliou E, Jansen KI, Olieric N, Standfuss J, Kapitein LC, Lohmüller T, Ahlfeld J, Akhmanova A, Steinmetz MO and Thorn-Seshold O (2021). A Robust, GFP-Orthogonal Photoswitchable Inhibitor Scaffold Extends Optical Control over the Microtubule Cytoskeleton. Cell Chem Biol., 28, 228-241.e6. https://doi.org/10.1016/j.chembiol.2020.11.007
Gnan S, Flyamer IM, Klein KN, Castelli E, Rapp A, Maiser A, Chen N, Weber P, Enervald E, Cardoso MC, Bickmore WA, Gilbert DM and Buonomo SCB (2021). Nuclear organisation and replication timing are coupled through RIF1–PP1 interaction. Nat Commun., 12, 2910. https://doi.org/10.1038/s41467-021-22899-2
Levone BR, Lenzken SC, Antonaci M, Maiser A, Rapp A, Conte F, Reber S, Mechtersheimer J, Ronchi AE, Mühlemann O, Leonhardt H, Cardoso MC, Ruepp MD and Barabino SML (2021). FUS-dependent liquid-liquid phase separation is important for DNA repair initiation. J Cell Biol., 220, e202008030. https://doi.org/10.1083/jcb.202008030
Schneid S, Wolff F, Buchner K, Bertram N, Baygün S, Barbosa P, Mangal S and Zanin E (2021). The BRCT domains of Ect2 have distinct functions during cytokinesis. Cell Reports, 34, 108805. https://doi.org/10.1016/j.celrep.2021.108805
Schwach J, Kolobynina K, Brandstetter K, Gerlach M, Ochtrop P, Helma J, Hackenberger CPR, Harz H, Cardoso MC, Leonhardt H and Stengl A (2021). Site-Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy. Chembiochem., 22, 1205-1209. https://doi.org/10.1002/cbic.202000727
Uhl E, Wolff F, Mangal S, Dube H and Zanin E (2021). Light-Controlled Cell-Cycle Arrest and Apoptosis. Angew Chem Int Ed Engl., 60, 1187-1196. https://doi.org/10.1002/anie.202008267
2020
Borowiak M, Küllmer F, Gegenfurtner F, Peil S, Nasufovic V, Zahler S, Thorn-Seshold O, Trauner D and Arndt HD (2020). Optical Manipulation of F-Actin with Photoswitchable Small Molecules. J Am Chem Soc., 142, 9240-9249. https://doi.org/10.1021/jacs.9b12898
Cremer M, Brandstetter K, Maiser A, Rao SSP, Schmid VJ, Guirao-Ortiz M, Mitra N, Mamberti S, Klein KN, Gilbert DM, Leonhardt H, Cardoso MC, Lieberman Aiden E, Harz H and Cremer T (2020). Cohesin depleted cells rebuild functional nuclear compartments after endomitosis. Nat Commun., 11, 6146. https://doi.org/10.1038/s41467-020-19876-6
Le Poul Y, Xin Y, Ling L, Mühling B, Jaenichen R, Hörl D, Bunk D, Harz H, Leonhardt H, Wang Y, Osipova E, Museridze M, Dharmadhikari D, Murphy E, Rohs R, Preibisch S, Prud’homme B and Gompel N (2020). Regulatory encoding of quantitative variation in spatial activity of a Drosophila enhancer. Sci. Adv., 6, eabe2955. https://doi.org/10.1126/sciadv.abe2955
Maiser A, Dillinger S, Längst G, Schermelleh L, Leonhardt H and Németh A (2020). Super-resolution in situ analysis of active ribosomal DNA chromatin organization in the nucleolus. Sci Rep., 10, 7462. https://doi.org/10.1038/s41598-020-64589-x
Müller-Deku A, Meiring JCM, Loy K, Kraus Y, Heise C, Bingham R, Jansen KI, Qu X, Bartolini F, Kapitein LC, Akhmanova A, Ahlfeld J, Trauner D and Thorn-Seshold O (2020). Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton. Nat Commun., 11, 4640. https://doi.org/10.1038/s41467-020-18389-6
Rausch C, Weber P, Prorok P, Hörl D, Maiser A, Lehmkuhl A, Chagin V, Casas-Delucchi CS, Leonhardt H and Cardoso MC (2020). Developmental differences in genome replication program and origin activation. Nucleic Acids Res., 48, 12751-12777. https://doi.org/10.1093/nar/gkaa1124
Schmitt S, Tahk S, Lohner A, Hänel G, Maiser A, Hauke M, Patel L, Rothe M, Josenhans C, Leonhardt H, Griffioen M, Deiser K, Fenn NC, Hopfner KP and Subklewe M (2020). Fusion of bacterial flagellin to a dendritic cell-targeting αCD40 antibody construct coupled with viral or leukemia-specific antigens enhances dendritic cell maturation and activates peptide-responsive T cells. Frontiers in Immunology, 11, 602802. https://doi.org/10.3389/fimmu.2020.602802
2019
Hörl D, Rojas Rusak F, Preusser F, Tillberg P, Randel N, Chhetri RK, Cardona A, Keller PJ, Harz H, Leonhardt H, Treier M and Preibisch S (2019). BigStitcher: Reconstructing high-resolution image datasets of cleared and expanded samples. Nature Methods, 16, 870-874. https://doi.org/10.1038/s41592-019-0501-0
Mahamid J, Tegunov D, Maiser A, Arnold J, Leonhardt H, Plitzko JM and Baumeister W (2019). Liquid-crystalline phase transitions in lipid droplets are related to cellular states and specific organelle association. Proc Natl Acad Sci U S A, 116, 16866-16871. https://doi.org/10.1073/pnas.1903642116
Wagner A, Hofmeister O, Rolland SG, Maiser A, Aasumets K, Schmitt S, Schorpp K, Feuchtinger A, Hadian K, Schneider S, Zischka H, Leonhardt H, Conradt B, Gerhold JM and Wolf A (2019). Mitochondrial Alkbh1 localises to mtRNA granules and its knockdown induces mitochondrial UPR in humans and C. elegans. J. Cell Sci., 132, 19. https://doi.org/10.1242/jcs.223891
2018
Chiu HY, Bates JA, Helma J, Engelke H, Harz H, Bein T and Leonhardt H (2018). Nanoparticle Mediated Delivery and Small Molecule Triggered Activation of Proteins in the Nucleus. Nucleus, 9, 530-542. https://doi.org/10.1080/19491034.2018.1523665
Feldmann DP, Cheng Y, Kandil R, Xie Y, Mohammadi M, Harz H, Sharma A, Peeler DJ, Moszczynska A, Leonhardt H, Pun SH and Merkel OM (2018). In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells. J Control Release, 276, 50-58. https://doi.org/10.1016/j.jconrel.2018.02.017
Middleton AM, Dal Bosco C, Chlap P, Bensch R, Harz H, Ren F, Bergmann S, Wend S, Weber W, Hayashi KI, Zurbriggen MD, Uhl R, Ronneberger O, Palme K, Fleck C and Dovzhenko A (2018). Data-Driven Modeling of Intracellular Auxin Fluxes Indicates a Dominant Role of the ER in Controlling Nuclear Auxin Uptake. Cell Rep., 22, 3044-3057. https://doi.org/10.1016/j.celrep.2018.02.074
Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermüller J, Leonhardt H, Sharma S, Niessing D and Heissmeyer V (2018). Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. Nat Commun., 9, 299. https://doi.org/10.1038/s41467-017-02582-1
Reiter K, Polzer H, Krupka C, Maiser A, Vick B, Rothenberg-Thurley M, Metzeler KH, Dörfel D, Salih HR, Jung G, Nößner E, Jeremias I, Hiddemann W, Leonhardt H, Spiekermann K, Subklewe M and Greif PA (2018). Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia. Leukemia, 32, 313-322. https://doi.org/10.1038/leu.2017.257
2017
Andreeva L, Hiller B, Kostrewa D, Lässig C, de Oliveira Mann CC, Jan Drexler D, Maiser A, Gaidt M, Leonhardt H, Hornung V and Hopfner KP (2017). cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders. Nature, 549, 394-398. https://doi.org/10.1038/nature23890
Balaji R, Bielmeier C, Harz H, Bates J, Stadler C, Hildebrand A and Classen AK (2017). Calcium spikes, waves and oscillations in a large, patterned epithelial tissue. Sci Rep., 7, 42786. https://doi.org/10.1038/srep42786
Cremer M, Schmid VJ, Kraus F, Markaki Y, Hellmann I, Maiser A, Leonhardt H, John S, Stamatoyannopoulos J and Cremer T (2017). Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters. Epigenetics Chromatin, 10, 39. https://doi.org/10.1186/s13072-017-0146-0
Essig K, Hu D, Guimaraes JC, Alterauge D, Edelmann S, Raj T, Kranich J, Behrens G, Heiseke A, Floess S, Klein J, Maiser A, Marschall S, Hrabĕ de Angelis M, Leonhardt H, Calkhoven CF, Noessner E, Brocker T, Huehn J, Krug AB, Zavolan M, Baumjohann D and Heissmeyer V (2017). Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells. Immunity, 47, 1067-1082.e12. https://doi.org/10.1016/j.immuni.2017.11.008
Kraus F, Miron E, Demmerle J, Chitiashvili T, Budco A, Alle Q, Matsuda A, Leonhardt H, Schermelleh L and Markaki Y (2017). Quantitative 3D structured illumination microscopy of nuclear structures. Nat Protoc, 12, 1011-1028. https://doi.org/10.1038/nprot.2017.020
Natale F, Rapp A, Yu W, Maiser A, Harz H, Scholl A, Grulich S, Anton T, Hörl D, Chen W, Durante M, Taucher-Scholz G, Leonhardt H and Cardoso MC (2017). Identification of the elementary structural units of the DNA damage response. Nat Commun., 8, 15760. https://doi.org/10.1038/ncomms15760
Schlenker R, Olguín-Contreras LF, Leisegang M, Schnappinger J, Disovic A, Rühland S, Nelson PJ, Leonhardt H, Harz H, Wilde S, Schendel DJ, Uckert W, Willimsky G and Noessner E (2017). Chimeric PD-1:28 receptor upgrades low-avidity T cells and restores effector function of tumor-infiltrating lymphocytes for adoptive cell therapy. Cancer Res., 77, 3577-3590. https://doi.org/10.1158/0008-5472.CAN-16-1922
Schueder F, Strauss MT, Hoerl D, Schnitzbauer J, Schlichthaerle T, Strauss S, Yin P, Harz H, Leonhardt H and Jungmann R (2017). Universal Super-Resolution Multiplexing by DNA Exchange. Angew Chem Int Ed Engl., 56, 4052-4055. https://doi.org/10.1002/anie.201611729
Ungewiß H, Vielmuth F, Suzuki ST, Maiser A, Harz H, Leonhardt H, Kugelmann D, Schlegel N and Waschke J (2017). Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase. Sci Rep., 7, 6329. https://doi.org/10.1038/s41598-017-06713-y
2016
Bielmeier C, Alt S, Weichselberger V, La Fortezza M, Harz H, Jülicher F, Salbreux G and Classen AK (2016). Interface Contractility between Differently Fated Cells Drives Cell Elimination and Cyst Formation. Curr Biol., 26, 563-74. https://doi.org/10.1016/j.cub.2015.12.063
Chagin VO, Casas-Delucchi CS, Reinhart M, Schermelleh L, Markaki Y, Maiser A, Bolius JJ, Bensimon A, Fillies M, Domaing P, Rozanov YM, Leonhardt H and Cardoso MC (2016). 4D Visualization of replication foci in mammalian cells corresponding to individual replicons. Nat Commun., 7, 11231. https://doi.org/10.1038/ncomms11231
Crevenna AH, Blank B, Maiser A, Emin D, Prescher J, Beck G, Kienzle C, Bartnik K, Habermann B, Pakdel M, Leonhardt H, Lamb DC and von Blume J (2016). Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network. J Cell Biol., 213, 305-14. https://doi.org/10.1083/jcb.201601089
Popken J, Schmid VJ, Strauss A, Guengoer T, Wolf E and Zakhartchenko V (2016). Stage-dependent remodeling of the nuclear envelope and lamina during rabbit early embryonic development. J Reprod Dev., 62, 127-35. https://doi.org/10.1262/jrd.2015-100
Hübner B, Lomiento M, Mammoli F, Illner D, Markaki Y, Ferrari S, Cremer M and Cremer T (2015). Remodeling of nuclear landscapes during human myelopoietic cell differentiation maintains co-aligned active and inactive nuclear compartments. Epigenetics Chromatin, 8, 47. https://doi.org/10.1186/s13072-015-0038-0
Qin W, Wolf P, Liu N, Link S, Smets M, Mastra F, Forné I, Pichler G, Hörl D, Fellinger K, Spada F, Bonapace IM, Imhof A, Harz H and Leonhardt H (2015). DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination. Cell Res., 25, 911-29. https://doi.org/10.1038/cr.2015.72
Rühland S, Wechselberger A, Spitzweg C, Huss R, Nelson PJ and Harz H (2015). Quantification of in vitro mesenchymal stem cell invasion into tumor spheroids using selective plane illumination microscopy. J Biomed Opt., 20, 040501. https://doi.org/10.1117/1.JBO.20.4.040501